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In the latest centralized purchase of sitagliptin tablets, the price dropped to less than 20 cents per tablet, with a drop of over 90%. The reporter learned at the scene of the tenth batch of drug centralized purchase that more than 30 companies bid for sitagliptin, which is known as the largest variety in this centralized purchase, including Huahai Pharmaceutical, Kelun Pharmaceutical, Zhengda Tianqing, tonghua dongbao, Zhejiang Pharmaceutical, Jiudian Pharmaceutical, Shiyao Ouyi, Chenxin Pharmaceutical and many other companies. Judging from the bidding results, the lowest bid price among enterprises has dropped below 0.2 yuan per piece, which is more than 90% lower than the limit price. Statistics show that in 2023, the sales of this product in the terminals of public medical institutions in China exceeded 2 billion yuan, and the sales of Merck, the original research manufacturer, accounted for more than 90%, so there is a large room for generic drug substitution. The quotation of Meradong in this collection is about 7.37 yuan per piece. (science and technology innovation board Daily)The Nikkei 225 index just broke through the 39,900.00 mark, and the latest report was 39,899.07, up 1.34% in the day.This year's 2 trillion special bonds for replacing hidden debts have all disclosed that the planned issuance amount of six provinces exceeds 10 million. According to the documents disclosed on China Bond Information Network, Beijing plans to issue 4.7 billion yuan of special bonds for refinancing to replace existing hidden debts, of which the issuance scale of 3-year, 7-year and 10-year special bonds for refinancing is 800 million yuan, 2.725 billion yuan and 1.175 billion yuan respectively. It is worth mentioning that since November 12, the total amount of refinancing special bonds to be issued or issued to replace existing implicit debts has reached 2 trillion yuan. This means that all the refinancing special bonds used by local governments to replace hidden debts have been disclosed this year. (澎湃)

London Metal Exchange (LME): aluminum stocks decreased by 2,500 tons, copper stocks decreased by 75 tons, nickel stocks decreased by 2,862 tons, lead stocks decreased by 2,250 tons, tin stocks were flat, and zinc stocks decreased by 1,300 tons.The OpenAI webpage shows that API, ChatGPT and Sora are all running normally.Ai Kelan: Liu Yi, the actual controller, intends to transfer 5% of the company's shares by agreement, with a total transaction price of 82.44 million yuan. Liu Yi, the controlling shareholder and actual controller, signed a share transfer agreement with Guangdong Nanchuan Private Equity Fund Management Co., Ltd., and Liu Yi intends to transfer 4 million unrestricted shares of the company (accounting for 5% of the company's total share capital) to Nanchuan Private Equity through agreement transfer. The transfer price is 20.61 yuan per share, and the total transaction price is 82.44 million yuan. This change in equity will not lead to changes in the controlling shareholder or actual controller of the company, and will not lead to changes in the control rights of listed companies.

The 2.53 billion shares held by Greenland Group have been frozen. According to the legal litigation information of Tianyancha, recently, Guangxi Construction Engineering Group Co., Ltd. added a piece of information on the freezing of shares. The executor is Greenland Holding Group Co., Ltd., and the amount of frozen shares is about 2.53 billion RMB. The freezing period is from December 9, 2024 to December 8, 2027. The enforcement court is Wanzhou District People's Court in Chongqing.Network Information Office: The Network Security Standards Committee should speed up the development and release of standards such as "Identification Method of Synthetic Content Generated by Artificial Intelligence" and strengthen the research on relevant network security standards such as intelligent networked vehicles. The second "Standards Week" of the National Network Security Standardization Technical Committee in 2024 was held in Haikou City, Hainan Province from December 8 th to 11 th. Wang Jingtao, deputy director of the National Network Information Office, pointed out that standing at a new starting point and a new journey, the Network Security Standards Committee should do a solid job in network security standardization. First, it is necessary to build a national network security defense system supported by standards, and promote the release and implementation of standards such as the boundary determination method of key information infrastructure, the index system of security protection capability, the alarm information format of network security products, and the asset information format as soon as possible, and accelerate the formation of systematic defense capabilities. Second, it is necessary to use standards to help data security governance and supervision, speed up the development of standards such as data classification and classification protection requirements and compliance audit of personal information protection, and ensure the safe and orderly flow of data. Third, it is necessary to lead the safe and orderly development of new technologies and applications such as artificial intelligence with standards and norms, accelerate the development and release of standards such as "Identification Method of Synthetic Content Generated by Artificial Intelligence", and strengthen the research on relevant network security standards such as intelligent networked vehicles and autonomous driving, effectively escorting the safe development of emerging future industries. Fourth, we should use standards to boost the international influence of China's cybersecurity, continue to push China's cybersecurity standards "going global", do our best to run the SC27 international conference in the second half of 2025, and strive to achieve a double harvest of conference organization and conference technical achievements.The US media said that the Biden administration is considering imposing new sanctions on Russian oil trade. Informed sources: The details have yet to be finalized. The Bloomberg website reported on the 10th local time that the Biden administration is considering imposing new sanctions on Russian oil trade before Trump returns to the White House, and the specific details have yet to be finalized. The article said that the Biden administration is weighing new and stricter sanctions against Russia's lucrative oil trade, trying to increase pressure on the Kremlin before Trump returns to the White House. According to an insider who asked not to be named, the details of possible new measures are still being worked out, but Biden's team is considering imposing restrictions on some Russian oil exports. Up to now, the Russian side has not responded. (CCTV)